Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis


Nonsteroidal anti-inflammatory drugs (NSAIDs) have had primacy for decades in the treatment of rheumatoid arthritis. Their palliative value is undisputed, but their lack of effect on the course of disease has led many to recommend early intervention with the so-called disease-controlling drugs. However, most such drugs are ineffective, and alternative long term symptomatic therapies have not proven safer or as effective as NSAIDs. Therefore NSAIDs will continue to be used for control of residual pain and inflammatory symptoms. All NSAIDs are equivalent in therapeutic efficacy. Therefore, differences in cost, frequency of administration (compliance and convenience) and frequency of serious adverse effects are important considerations in choice of drug. Upper gastrointestinal bleeding and impairment of renal function are the adverse effects of greatest concern. Unequivocal proof that any NSAID is significantly safer than another is lacking

DOI: 10.1007/BF03259267

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@article{Dickson2012NonsteroidalAD, title={Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis}, author={John F. Dickson and Dr Robert F. Willkens}, journal={Clinical Immunotherapeutics}, year={2012}, volume={2}, pages={185-191} }