Nonsteroidal Anti-Inflammatory Drugs and Heart Failure

  title={Nonsteroidal Anti-Inflammatory Drugs and Heart Failure},
  author={Gys{\`e}le S. Bleumink and Johannes Feenstra and Miriam Sturkenboom and Bruno H. Stricker},
Heart failure constitutes an increasing public health problem because of the growing incidence and prevalence, poor prognosis and high hospital (re)admission rates. Myocardial infarction is the underlying cause in the majority of patients, followed by hypertension, valvular heart disease and idiopathic cardio-myopathy.Nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit the enzymes cyclo-oxygenase (COX) 1 and 2, have been associated with the occurrence of symptoms of heart failure in… 
Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications.
  • S. Harirforoosh, Waheed Asghar, F. Jamali
  • Medicine
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2013
The GI toxicity of the NSAIDs is discussed, lower but still therapeutics doses of some NSAIDs may be cardioprotective and their renal and CV adverse effects are assessed.
Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study
The risk of hospital admission for heart failure associated with current use of NSAIDs appears to vary between individual NSAIDs, and this effect is dose dependent.
Drug-Induced Heart Failure (Part 2: Mechanisms of Development, Clinical Signs, Differential Diagnosis, Risk Factors, Treatment and Prevention)
The study revealed various mechanisms of heart failure development following drug treatment, including the cardiotoxic effects of a particular drug, as well as methods of prevention and treatment of drug-induced heart failure when using groups of drugs.
Adverse Effects of Nonsteroidal Anti-inflammatory Drugs on the Cardiovascular System
Nonsteroidal anti-inflammatory drugs (NSAIDs) are very effective medications, but their use is associated with a broad spectrum of adverse reactions involving the liver, kidney, cardiovascular (CV)
Heart Failure: Management and Prevention of Heart Failure Based on Current Understanding of Pathophysiological Mechanisms
The characteristics of progressive deterioration of the failing heart associated with cardiac remodeling and shortened life expectancy are crucial target for the treatment and are likely to accelerate advancement of understanding and pharmacological and genetic therapy in the field of prevention and management of heart failure.
Treatment of osteoarthritis in hypertensive patients
The management of osteoarthritis in the hypertensive patient is discussed, the evidence for the effects of paracetamol and NSAIDs on blood pressure is reviewed and novel therapeutic strategies for osteoartritis that might diminish this problem are discussed.
Non-steroidal anti-inflammatory drugs and increased risk of sudden cardiac death
Non-steroidal anti-inflammatory drugs, or NSAIDs, are commonly prescribed, and some are available as over-the-counter (OTC) medications to alleviate pain, inflammation, and fever associated with a
Management of Non-cardiac Co-morbidities in Chronic Heart Failure
Future trials should focus on optimal strategies for the comprehensive management of elderly patients with CHF with multiple co-morbidities, rather than the isolated effects of single drugs in younger patients with few or no co- Morbidities.
How to Improve Adherence to Life-saving Heart Failure Treatments with Potassium Binders.
Two new potassium-binding agents, patiromer and ZS-9, have been shown to be effective and safe for the treatment of hyperkalaemia, as well as the maintenance of normokalaemia and may allow for dose optimisation of RAAS inhibitors for the long-term maintenance and protection of the renal and cardiovascular system.
Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients.
NSAID use was associated with a lower risk of developing cancer in chronic dialysis patients; however, they should still be used with caution due to the side effects of gastrointestinal bleeding.


Adverse Cardiovascular Effects of NSAIDs in Patients with Congestive Heart Failure
Further pharmacoepidemiological research is needed to quantify the risk for CHF attributable to the use of NSAIDs and to identify patients who are particularly susceptible to the adverse cardiovascular effects of these agents.
[Drug-induced heart failure].
Congestive heart failure due to nonsteroidal anti-inflammatory drugs in the elderly.
The results of this study provide further evidence that congestive heart failure due to nonsteroidal anti-inflammatory drug treatment is a probable adverse drug reaction in elderly individuals with or without a history of impaired cardiac performance.
Non-steroidal anti-inflammatory drugs and angiotensin converting enzyme inhibitors: a commonly prescribed combination with variable effects on renal function.
Both non-steroidal anti-inflammatory agents (NSAIDs) and angiotensin converting enzyme (ACE) inhibitors are finding increasing usage in many therapeutic areas and the purpose of this review is to summarise the renal and hormonal effects of such a combination.
Nonsteroidal anti-inflammatory drugs and antihypertensives.
  • M. Houston
  • Medicine
    The American journal of medicine
  • 1991
Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure: the Rotterdam Study.
In patients with prevalent heart failure, current use of NSAIDs is associated with a substantially increased risk of a relapse, and the use ofNSAIDs is not associated with an increasedrisk of incident heart failure.