Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Musculoskeletal Soft-Tissue Healing: A Scoping Review.

  title={Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Musculoskeletal Soft-Tissue Healing: A Scoping Review.},
  author={Niloy Ghosh and Oluwadamilola Kolade and Edward C Shontz and Yoav Rosenthal and Joseph D. Zuckerman and Joseph A Bosco and Mandeep Singh Virk},
  journal={JBJS reviews},
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are being increasingly employed as a part of multimodal non-opioid strategies to treat postoperative pain. In the present study, we sought to review the effects of short-term NSAID use on musculoskeletal soft-tissue healing. METHODS We performed a scoping review of all studies that included the use of NSAIDs and their effect on healing of soft tissues, which for the purpose of this review refers to non-osseous musculoskeletal tissue… 

Local and Intra-articular Administration of Nonsteroidal Anti-inflammatory Drugs for Pain Management in Orthopedic Surgery

There is convincing evidence that NSAIDs administered locally in and around the joint reduce postoperative pain scores and opioid consumption in patients undergoing total joint arthroplasty, yet further research is required regarding the risks of potential chondrotoxicity and the inhibition of bone and soft-tissue healing with locally administered NSAIDs.

Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review

The main outcome is that vitamin C supplementation is potentially useful as a therapeutic approach for tendinopathy recovery, and increases collagen synthesis with a consequent improvement in the patient’s condition.

Evaluation of Therapeutic Effects of Quercetin Against Achilles Tendinopathy in Rats via Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Metalloproteinases

Quercetin showed antioxidant, anti–inflammatory, antiapoptotic, and antiautophagic effects on tendons against tendinopathy, and has protective properties against collagenase–induced tendon damage in rats.


  • F. Hladkykh
  • Medicine, Biology
    Medical Science of Ukraine (MSU)
  • 2021
The combined use of CPE and DS is superior in therapeutic activity to monotherapy with this nonsteroidal anti-inflammatory drug of experimental rheumatoid arthritis.

Perioperative Pain Management in Ambulatory and Inpatient Shoulder Surgery.

Centrally acting analgesics such as tramadol have been shown to be as effective as opioids and have a lower risk of complications, and nerve blocks are an excellent addition to multimodal pain management strategies.

Reparative and Maladaptive Inflammation in Tendon Healing

Recent findings in the immunobiology of tendon healing are highlighted, focusing on the cells and cytokines involved in reparative inflammation.

Effect of vacuum sealing drainage on healing time and inflammation‐related indicators in patients with soft tissue wounds

VSD has a significant effect on the treatment of patients with soft-tissue wounds, which can effectively shorten the time of wound healing and reduce inflammation-related indicators.

Creating an Optimal In Vivo Environment to Enhance Outcomes Using Cell Therapy to Repair/Regenerate Injured Tissues of the Musculoskeletal System

How the interface between inflammation and cell-based regeneration of damaged tissues may be at odds is discussed, and approaches to improve outcomes are outlined.

Advances toward transformative therapies for tendon diseases

Advances in the development of novel drugs, biologic products, and biomaterial therapies for tendon diseases with perspectives for translation of integrated therapies are summarized.



The effects of COX-2 anti-inflammatory drugs on soft tissue healing: a review of the literature.

These drugs should, however, be evaluated carefully with regards to gastrointestinal events and their still poorly defined effect on tissue healing, and traditional anti-inflammatory drugs are a safer treatment for patients with a high cardiovascular risk.

NSAID therapy effects on healing of bone, tendon, and the enthesis.

The mechanisms by which bone, tendon, and enthesis healing occurs, and the effects of NSAID therapy on each of these processes are summarized.

Negative effects of parecoxib and indomethacin on tendon healing: an experimental study in rats

A significantly lower tensile strength was found in rats given both parecoxib and indomethacin compared to the control group and stiffness in the healing tendons was significantly lower in the pare Coxib group compared to both the placebo and the indometHacin groups.

The Effect of Analgesic Agents on the Healing Rat Medial Collateral Ligament

Piroxicam improves ligament healing, but this effect cannot be attributed to all nonselective nonsteroidal anti-inflammatory drugs, and Opiate analgesics, acetaminophen, and cyclooxygenase-2 inhibitors do not appear to categorically affect ligament Healing.

The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats.

Significantly lower maximum pull-out strength, energy absorption, stiffness and stiffness were found in rats given parecoxib and indometacin compared with the control group, most pronounced with parcoxib.

Indomethacin and Celecoxib Impair Rotator Cuff Tendon-to-Bone Healing

Traditional and cyclooxygenase-2–specific nonsteroidal anti-inflammatory drugs significantly inhibited tendon-tobone healing in rats, and this inhibition appears linked to cyclo oxygengen enzyme-2.

A Cyclooxygenase-2 Inhibitor Impairs Ligament Healing in the Rat

The results of this study do not support use of cyclooxygenase-2 specific inhibitors in the treatment of ligament injuries.

Do nonsteroidal anti-inflammatory drugs affect the outcome of arthroscopic Bankart repair?

Prescription of short‐term post‐operative NSAID treatment in the post-operative period did not influence on the functional outcome after arthroscopic Bankart procedures.

The Effect of Limited Perioperative Nonsteroidal Anti-inflammatory Drugs on Patients Undergoing Anterior Cruciate Ligament Reconstruction

Administration of NSAIDs to patients after ACLR does not have a negative effect on graft survival, risk of revision, or risk of a KOOS-QOL score <44 at 2-year follow-up.

The Effects of Common Anti-Inflammatory Drugs on the Healing Rat Patellar Tendon

Anti-inflammatory drugs, with the exception of ibuprofen, had a detrimental effect on healing strength at the bone-tendon junction as demonstrated by decreased failure loads and increased failures of the cerclage suture.