Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Musculoskeletal Soft-Tissue Healing: A Scoping Review.

@article{Ghosh2019NonsteroidalAD,
  title={Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Musculoskeletal Soft-Tissue Healing: A Scoping Review.},
  author={Niloy Ghosh and Oluwadamilola O Kolade and Edward Shontz and Yoav Rosenthal and Joseph D. Zuckerman and Joseph A Bosco and Mandeep S. Virk},
  journal={JBJS reviews},
  year={2019}
}
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are being increasingly employed as a part of multimodal non-opioid strategies to treat postoperative pain. In the present study, we sought to review the effects of short-term NSAID use on musculoskeletal soft-tissue healing. METHODS We performed a scoping review of all studies that included the use of NSAIDs and their effect on healing of soft tissues, which for the purpose of this review refers to non-osseous musculoskeletal tissue… Expand
7 Citations
Local and Intra-articular Administration of Nonsteroidal Anti-inflammatory Drugs for Pain Management in Orthopedic Surgery.
TLDR
There is convincing evidence that NSAIDs administered locally in and around the joint reduce postoperative pain scores and opioid consumption in patients undergoing total joint arthroplasty, yet further research is required regarding the risks of potential chondrotoxicity and the inhibition of bone and soft-tissue healing with locally administered NSAIDs. Expand
Healing rates after rotator cuff repair for patients taking either celecoxib or placebo: a double-blind randomized controlled trial
TLDR
Half of the patients who received celecoxib had an intact repair compared with 70% intact repair for patients receiving placebo, although not statistically significant in this small study, larger studies are needed to clarify this important clinical concern. Expand
EVALUATION OF THE THERAPEUTIC EFFECT OF THE COMBINED USE OF CRYOPRESERVED PLACENTA EXTRACT AND DICLOFENAC SODIUM IN EXPERIMENTAL RHEUMATOID ARTHRITIS BY HEMATOLOGICAL PARAMETERS
  • F. Hladkykh
  • Medicine
  • Medical Science of Ukraine (MSU)
  • 2021
Relevance. Cryopreserved placenta extract (CPE) increase the resistance of the mucous membrane of the gastrointestinal tract to the damaging effects of nonsteroidal anti-inflammatory drugs.Expand
Perioperative Pain Management in Ambulatory and Inpatient Shoulder Surgery.
TLDR
Centrally acting analgesics such as tramadol have been shown to be as effective as opioids and have a lower risk of complications, and nerve blocks are an excellent addition to multimodal pain management strategies. Expand
Reparative and Maladaptive Inflammation in Tendon Healing
TLDR
Recent findings in the immunobiology of tendon healing are highlighted, focusing on the cells and cytokines involved in reparative inflammation. Expand
Effect of vacuum sealing drainage on healing time and inflammation‐related indicators in patients with soft tissue wounds
TLDR
VSD has a significant effect on the treatment of patients with soft-tissue wounds, which can effectively shorten the time of wound healing and reduce inflammation-related indicators. Expand
Graft healing after anterior cruciate ligament reconstruction (ACLR)
  • Shiyi Yao, B. Fu, P. Yung
  • Medicine
  • Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology
  • 2021
TLDR
The purpose of this review is to combine both the known basic science & clinical evidence to provide a much clearer picture of the obstacle encountered in graft healing, so as to facilitate researchers on subsequent work on the enhancement of ACL graft healing. Expand

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