Nonsteroidal Anti‐inflammatory Drug‐Induced Reactions and Desensitization

@article{BergesGimeno2004NonsteroidalAD,
  title={Nonsteroidal Anti‐inflammatory Drug‐Induced Reactions and Desensitization},
  author={Mar{\'i}a Pilar Berges-Gimeno and Donald D. Stevenson},
  journal={Journal of Asthma},
  year={2004},
  volume={41},
  pages={375 - 384}
}
Since the synthesis of acetylsalicylic acid in 1897 by Felix Hoffmann, several pseudoallergic and allergic adverse reactions, caused by aspirin (ASA) and nonsteroidal anti‐inflammatory drugs (NSAID... 
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A case of tolerance induction to anti-TB drugs in a patient with SJS/TEN overlap syndrome is described using a specifically designed premedication, comedication, and desensitization protocol.
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General considerations on rapid desensitization for drug hypersensitivity – a consensus statement
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General considerations on rapid desensitization for drug hypersensitivity – a consensus statement.
Safety of 5-Aminosalicylic Acid Derivatives in Patients with Sensitivity to Acetylsalicylic Acid and Nonsteroidal Anti-inflammatory Drugs.
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There is a dearth of evidence demonstrating cross-reactivity between ASA or NSAID and 5-ASA, suggesting that the mechanism of action of this agent controls inflammation by inhibiting prostaglandin E2 and leukotrienes should be investigated.
Desensitization for hypersensitivity reactions to medications.
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The molecular basis of RDD has now been studied, and an in vitro mouse mast cell model has shown that RDD is an antigen-specific process that does not induce subclinical mast cellmediator release, and that blocks the release of acute and late mast cell mediators by preventing calcium influx and antigen/IgE/and IgE receptor internalization.
Management Options for Patients with Aspirin and Nonsteroidal Antiinflammatory Drug Sensitivity
TLDR
Management of patients with aspirin/NSAID sensitivity includes avoidance of aspirin/nonselectiveNSAIDs, use of COX-2 selective NSAIDs, acetaminophen in doses less than 1000 mg, and desensitization.
Desensitization to antibiotics in children
  • J. Cernadas
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    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2013
To cite this article: Cernadas JR. Educational case series: Desensitization to antibiotics in children. Pediatr Allergy Immunol 2012.
Anaphylactic and anaphylactoid causes of angioedema.
  • P. Greenberger
  • Medicine
    Immunology and allergy clinics of North America
  • 2006
Desensitization for drug allergy
  • M. Castells
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2006
TLDR
Standardized protocols for treating adverse reactions to antibiotics and aspirin allow for treatment of critically infected patients and aspirin-sensitive cardiac patients, and should be implemented as the standard of care.
Analgesics, Narcotic Antagonists, and Drugs Used to Treat Arthritis
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