Nonstationary disposition of valproic acid during prolonged intravenous infusion: contributions of unbound clearance and protein binding.

@article{Arens2001NonstationaryDO,
  title={Nonstationary disposition of valproic acid during prolonged intravenous infusion: contributions of unbound clearance and protein binding.},
  author={Thomas Arens and Gary M. Pollack},
  journal={Biopharmaceutics & drug disposition},
  year={2001},
  volume={22 6},
  pages={243-9}
}
Circadian variations in disposition have been observed for a variety of agents, including anticonvulsants. Valproic acid (VPA), an anticonvulsant used to control generalized and partial seizures, has exhibited diurnal oscillations in steady-state concentrations during long-term administration to humans and non-human primates. The present study was conducted to assess potential diurnal changes in the disposition of VPA during prolonged i.v. infusion in rats. Animals, maintained on a strict 12-h… CONTINUE READING