Nonspecific protein adsorption at the single molecule level studied by atomic force microscopy.

@article{Schn2007NonspecificPA,
  title={Nonspecific protein adsorption at the single molecule level studied by atomic force microscopy.},
  author={Peter M Sch{\"o}n and Martin G{\"o}rlich and Michiel J. J. Coenen and Hans A Heus and Sylvia Speller},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2007},
  volume={23 20},
  pages={9921-3}
}
Liquid tapping atomic force microscopy was used to study the nonspecific adsorption of horse spleen ferritin at a bare gold surface at single molecule resolution. The majority of ferritin molecules adsorbed irreversible on gold surfaces in accordance with the random sequential adsorption (RSA) mechanism frequently used to describe irreversible adsorption processes. However, the time-resolved data also reveal events that go beyond the RSA model, i.e., lateral mobility and fragility of some… CONTINUE READING