Nonspecific medication side effects and the nocebo phenomenon.

@article{Barsky2002NonspecificMS,
  title={Nonspecific medication side effects and the nocebo phenomenon.},
  author={Arthur Joseph Barsky and Ralph Saintfort and Malcolm P. Rogers and Jonathan F. Borus},
  journal={JAMA},
  year={2002},
  volume={287 5},
  pages={
          622-7
        }
}
Patients taking active medications frequently experience adverse, nonspecific side effects that are not a direct result of the specific pharmacological action of the drug. Although this phenomenon is common, distressing, and costly, it is rarely studied and poorly understood. The nocebo phenomenon, in which placebos produce adverse side effects, offers some insight into nonspecific side effect reporting. We performed a focused review of the literature, which identified several factors that… Expand
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