Nonspecific inhibitor of DNA synthesis elaborated by T-acceptor cells. II. Requirements for its production and action.

@article{Malkovsk1986NonspecificIO,
  title={Nonspecific inhibitor of DNA synthesis elaborated by T-acceptor cells. II. Requirements for its production and action.},
  author={Miroslav Malkovsk{\'y} and Vittorio Colizzi and Geoffrey L. Asherson and Josef Krej{\vc}{\'i} and Teresa H Bacon and Madeleine C. Watkins and Marek Zembala},
  journal={Cellular immunology},
  year={1986},
  volume={98 1},
  pages={114-24}
}
The production of a nonspecific inhibitor of DNA synthesis (nsINH) appears to be one of the final events in the T-suppressor cell circuit in mice exposed to contact sensitizers. We report here that: The nsINH suppresses the proliferative response to a polyclonal T-cell mitogen, concanavalin A (Con A), regardless of the dose of Con A used. It also suppresses DNA synthesis in lymphoid cells stimulated with alloantigens. This suppression can be completely eliminated by adding exogenous interleukin… CONTINUE READING