Nonspecific Cell‐Mediated Immunity in Patients with Epidermodysplasia Verruciformis

@article{Oliveira2003NonspecificCI,
  title={Nonspecific Cell‐Mediated Immunity in Patients with Epidermodysplasia Verruciformis},
  author={Walmar Roncalli Pereira de Oliveira and Solange Carrasco and Cyro Festa Neto and Peter L. Rady and Stephen K. Tyring},
  journal={The Journal of Dermatology},
  year={2003},
  volume={30}
}
Epidermodysplasia verruciformis (EV) is a rare disease that usually begins in childhood and is characterized by a generalized infection by human papilloma virus (HPV), frequent associations with cutaneous carcinomas, and abnormalities of cell‐mediated immunity (CMI). We studied nonspecific CMI in 13 patients with EV by bacterial skin tests, allergic reactions to dinitrochlorobenzene (DNCB), measurement of responses to phytohemagglutinin (PHA), and quantification of T lymphocytes and T… 
Epidermodysplasia verruciformis.
TLDR
The EV model of cutaneous SCC may be applied to the general population; it is suggested that the TMC mutations impair the immunity of the patients, supporting the amplification of specific HPV types.
EVER2 Deficiency is Associated with Mild T-cell Abnormalities
TLDR
The findings suggest that EVER2-deficient patients display mild T-cell abnormalities, and it remains unclear whether these abnormalities result from EVER deficiency, chronic EV-HPV infection, or both.
Epidermodysplasia Verruciformis Associated with Myelodysplastic Syndrome: An Intriguing Association
TLDR
It is hypothesized that the pathomechanisms, including the role of oncogenes and cytokines, are connected to the progression to malignancy in these settings.
Genetics of Epidermodysplasia Verruciformis
TLDR
Clinical and histologic findings, EV-HPV, cutaneous oncogenesis, and genetics will be briefly reviewed.
Epidermodysplasia verruciformis and human immunodeficiency virus infection: a distinct entity?
  • M. Daly, R. Hay
  • Medicine
    Current opinion in infectious diseases
  • 2012
TLDR
One of the challenges for clinicians is to establish if the clinical phenotype in HIV-positive patients diagnosed with epidermodysplasia verruciformis is identical to that seen in those with the inherited form of the disease.
Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses.
  • G. Orth
  • Biology, Medicine
    Seminars in immunology
  • 2006
TLDR
The hypothesis is that EVER proteins act as restriction factors for EV-specific HPVs in keratinocytes, and that EV represents a primary deficiency of intrinsic immunity against certain papillomaviruses.
Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis.
  • G. Orth
  • Biology, Medicine
    Current topics in microbiology and immunology
  • 2008
TLDR
Keratinocytes, the home cells of HPVs, are likely to play a central role in both EV and HPV-5 infections, and the transmembrane viral E5/E8 and cellular EVER proteins interact both with the zinc transporter ZnT1, and arelikely to modulate zinc homeostasis.
EVER2 Deficiency is Associated with Mild
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by persistent flat warts or pityriasis versicolor-like lesions caused by betapapillomavi- ruses (EV-HPVs). Autosomal
A novel approach to the classification of epidermodysplasia verruciformis
TLDR
The term “acquired” epidermodysplasia verruciformis was coined to describe an EV‐like syndrome that can develop in patients with a compromised immune system that is uniquely characterized by an increased susceptibility to specific human papillomavirus (HPV) genotypes.
Deleterious Effect of Radiation Therapy on Epidermodysplasia Verruciformis Patients
TLDR
Radiotherapy might be associated with progression of SCC in patients with EV, and it is recommended that radiotherapy should be avoided in this patient population.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Cell-mediated immunity in epidermodysplasia verruciformis.
TLDR
Only in cases with very advanced tumors CMI was impaired parallel to the gravity of the patient's general condition, and was greater in cases of long duration and with extensive lesions.
T cell defect in patients with epidermodysplasia verruciformis due to human papillomavirus type 3 and 5.
TLDR
Most of the patients with epidermodysplasia verruciformis were anergic to sensitization to dinitrochlorobenzene (DNCB) and were shown to have a decreased number of T lymphocytes and reduced lymphocyte PHA responsiveness, which could indicate that malignancy in EV is related rather to the oncogenic potential of HPV-5 type than to the extent of T cell defect that was similar in both EV varieties.
Partial defects of cell-mediated immunity in patients with epidermodysplasia verruciformis.
TLDR
The results suggest that cellular defects in patients with epidermodysplasia verruciformis did not relate to all functions of the immune system, and increased angiogenic capability of peripheral blood mononuclear cells in the majority of the patients.
Depressed immune function in epidermodysplasia verruciformis.
TLDR
Immunologic study of two siblings with Epidermodysplasia verruciformis demonstrated normal immunoglobulin levels, normal numbers of T-lymphocytes and B-LYmphocytes, but markedly depressed in vitro blastogenic reactivity to mitogens and antigens.
Clinical aspects of epidermodysplasia verruciformis
TLDR
Epidermodysplasia verruciformis is a rare genodermatosis characterized by a generalized infection with a specific group of human papilloma virus and a propensity for developing skin malignant tumours in 30%−50% of patients.
Specific cell-mediated immunity in patients with epidermodysplasia verruciformis and plane warts.
TLDR
A significant increase in specific cell-mediated reactivity concomitant with the regression of the warts is shown.
Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis.
: EV is an autosomal recessive disease which usually begins in infancy or childhood, with an average age of onset of 9. Flat warts are most common, but pityriasis-like warts occur in approximately
Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin.
TLDR
Epidermodysplasia verruciformis is a model not only of cutaneous viral oncogenesis but also of local defense mechanisms in the progression of human papillomavirus-associated cancers.
Aspectos clínicos da epidermodisplasia verruciforme
TLDR
The EV presents high familial incidence and an autosomal recessive mode of inheritance, which doesn't affect the scalp and mucous membrane, and the most frequent clinical manifestation is the "malignant" (62%), followed by "benignant" and "mixed"(15%).
Clinical observations, virologic studies, and treatment trials in patients with epidermodysplasia verruciformis, a disease induced by specific human papillomaviruses.
TLDR
EV serves as a model for studying the interplay of oncogenic viruses, genetic and immunologic factors, and sunlight in the production of skin cancer in humans.
...
1
2
...