Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

@article{Mendell2004NonsenseSR,
  title={Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise},
  author={Joshua T. Mendell and Neda A. Sharifi and Jennifer L Meyers and Francisco Mart{\'i}nez-Murillo and Harry C Dietz},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={1073-1078}
}
Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD). This pathway can modulate phenotypes arising from nonsense or frameshift mutations, but little is known about the physiologic role of NMD in higher eukaryotes. To address this issue, we examined expression profiles in mammalian cells depleted of Rent1 (also called hUpf1), a factor essential for NMD. Upregulated transcripts included those with upstream open reading… CONTINUE READING
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Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5¢ to 3¢ mRNA decay pathways in yeast

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