Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

@article{Gatfield2004NonsensemediatedMR,
  title={Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila},
  author={David Gatfield and Elisa Izaurralde},
  journal={Nature},
  year={2004},
  volume={429},
  pages={575-578}
}
In eukaryotic cells, messenger RNAs harbouring premature termination codons (PTCs) are rapidly degraded by a conserved post-transcriptional mechanism referred to as nonsense-mediated mRNA decay (NMD), which prevents the synthesis of truncated proteins that could be deleterious for the cell. Studies in yeast and mammals indicate that degradation by means of this pathway can occur from both the 5′ end of the message (involving decapping and 5′-to-3′ exonucleolytic digestion by XRN1) or the 3′ end… CONTINUE READING
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