Nonsense-mediated mRNA decay in mammals.

  title={Nonsense-mediated mRNA decay in mammals.},
  author={Lynne E Maquat},
  journal={Journal of cell science},
  volume={118 Pt 9},
Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exonexon junction (reviewed in Maquat, 2004a; Nagy and Maquat, 1998). Notably, dependence on exon-exon junctions distinguishes NMD in mammalian cells from NMD in all other organisms that have been examined, including Saccharomyces cerevisiae and Drosophila melanogaster (reviewed in Maquat, 2004b). NMD downregulates spliced mRNAs… CONTINUE READING

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