Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin.

@article{Linde2007NonsensemediatedMD,
  title={Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin.},
  author={Liat Linde and Stephanie Boelz and Malka Nissim-Rafinia and Yifat S. Oren and Michael Wilschanski and Yasmin Yaacov and Dov Virgilis and Gabriele Neu-Yilik and Andreas E Kulozik and Eitan Kerem and Batsheva Kerem},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 3},
  pages={683-92}
}
Aminoglycosides can readthrough premature termination codons (PTCs), permitting translation of full-length proteins. Previously we have found variable efficiency of readthrough in response to the aminoglycoside gentamicin among cystic fibrosis (CF) patients, all carrying the W1282X nonsense mutation. Here we demonstrate that there are patients in whom the level of CF transmembrane conductance regulator (CFTR) nonsense transcripts is markedly reduced, while in others it is significantly higher… CONTINUE READING
85 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

Similar Papers

Loading similar papers…