Nonsense-mediated mRNA decay

  title={Nonsense-mediated mRNA decay},
  author={Lynne E Maquat},
  journal={Current Biology},
Is it important? Absolutely! NMD probably evolved to eliminate abnormal transcripts due to routine errors in gene expression. For example, inefficient or inaccurate pre-mRNA splicing can generate an intron-derived in frame nonsense codon, or a shift in the reading frame and an exon-derived nonsense codon downstream of the shift. There are also natural substrates for NMD such as alternatively spliced mRNAs. NMD is essential for mammalian development: embryonic mice lacking both alleles encoding… CONTINUE READING
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