Nonsense-mediated mRNA decay (NMD) mechanisms

  title={Nonsense-mediated mRNA decay (NMD) mechanisms},
  author={Saverio Brogna and Jikai Wen},
  journal={Nature Structural &Molecular Biology},
Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In mammalian cells, NMD is also linked to pre-mRNA splicing, as in many instances strong mRNA reduction occurs only when the PTC is located upstream of an intron. It is proposed that in these systems, the exon junction complex (EJC) mediates the link between splicing and NMD. Recent studies have questioned the role of splicing and the EJC in… CONTINUE READING
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