Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors.

  title={Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors.},
  author={Jan Rehwinkel and Jeroen Raes and Elisa Izaurralde},
  journal={Trends in biochemical sciences},
  volume={31 11},
Recent genome-wide identification of nonsense-mediated mRNA decay (NMD) targets in yeast, fruitfly and human cells has provided insight into the biological functions and evolution of this mRNA quality control mechanism, revealing that NMD post-transcriptionally regulates an important fraction of the transcriptome. NMD targets are associated with a broad range of biological processes, but most of these targets are not encoded by orthologous genes across different species. Yeast and fruitfly NMD… CONTINUE READING
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