Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides

Abstract

Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson-Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic degradation of target RNA. ASOs designed to sterically block access of proteins to the RNA modulate mRNA… (More)
DOI: 10.1093/nar/gku184

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@inproceedings{Ward2014NonsensemediatedDA, title={Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides}, author={Amanda J. Ward and Michaela Norrbom and Seung Hyun Chun and Cathy Bennett and Frank Rigo}, booktitle={Nucleic acids research}, year={2014} }