Nonselective Suppression of Voltage-gated Currents by Odorants in the Newt Olfactory Receptor Cells

@article{Kawai1997NonselectiveSO,
  title={Nonselective Suppression of Voltage-gated Currents by Odorants
 in the Newt Olfactory Receptor Cells 
 },
  author={Fusao Kawai and Takashi Kurahashi and Akimichi Kaneko},
  journal={The Journal of General Physiology},
  year={1997},
  volume={109},
  pages={265 - 272}
}
Effects of odorants on voltage-gated ionic channels were investigated in isolated newt olfactory receptor cells by using the whole cell version of the patch-clamp technique. Under voltage clamp, membrane depolarization to voltages between -90 mV and +40 mV from a holding potential (Vh) of -100 mV generated time- and voltage-dependent current responses; a rapidly (< 15 ms) decaying initial inward current and a late outward current. When odorants (1 mM amyl acetate, 1 mM acetophenone, and 1 mM… CONTINUE READING
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