Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection

@article{Riley2016NonselectivePO,
  title={Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection},
  author={Sean P. Riley and Abigail I. Fish and Daniel Alejandro Garza and Kaikhushroo H. Banajee and Emma K. Harris and F{\'a}bio Del Piero and Juan Jos{\'e} Mart{\'i}nez},
  journal={Infection and Immunity},
  year={2016},
  volume={84},
  pages={790 - 797}
}
ABSTRACT Scientific analysis of the genus Rickettsia is undergoing a rapid period of change with the emergence of viable genetic tools. The development of these tools for the mutagenesis of pathogenic bacteria will permit forward genetic analysis of Rickettsia pathogenesis. Despite these advances, uncertainty still remains regarding the use of plasmids to study these bacteria in in vivo mammalian models of infection, namely, the potential for virulence changes associated with the presence of… 
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The Rickettsia conorii Adr1 Interacts with the C-Terminus of Human Vitronectin in a Salt-Sensitive Manner
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Significant Growth by Rickettsia Species within Human Macrophage-Like Cells Is a Phenotype Correlated with the Ability to Cause Disease in Mammals
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The ability of pathogenic rickettsial species to establish a niche within macrophage-like cells could be an important factor in their ability to cause disease in mammals.
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Different impacts on host inflammatory responses between species during infection are confirmed, demonstrating that these species trigger different levels of beta interferon (IFN-β), differences in the bioavailability of the proinflammatory cytokine interleukin 1β (IL-1β), and differences in triggering of pyroptotic events.
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