Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.

@article{Recktenwald2002NonribosomalBO,
  title={Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.},
  author={J{\"u}rgen Recktenwald and Riham M. Shawky and Oliver Puk and Frank Pfennig and Ulrich Keller and Wolfgang Wohlleben and Stefan Pelzer},
  journal={Microbiology},
  year={2002},
  volume={148 Pt 4},
  pages={
          1105-18
        }
}
During analysis of the recently identified gene cluster for the glycopeptide antibiotic balhimycin, produced by Amycolatopsis mediterranei DSM 5908, novel genes were identified and characterized in detail. The gene products of four of the identified genes (bpsA, bpsB, bpsC and bpsD) are nonribosomal peptide synthetases (NRPSs); one (Orf1-protein) shows similarities to small proteins associated with several NRPSs without an assigned function. BpsA and BpsB are composed of three modules each… CONTINUE READING

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