Nonredundant roles of the elongation factor MEN in postimplantation development.

  title={Nonredundant roles of the elongation factor MEN in postimplantation development.},
  author={Kinuko Mitani and Tetsuya Yamagata and Calvin Iida and Hiromi Oda and Kazuhiro Maki and Motoshi Ichikawa and Tohru Asai and Hiroaki Honda and Masato Kurokawa and Hisamaru Hirai},
  journal={Biochemical and biophysical research communications},
  volume={279 2},
The MEN/ELL gene was cloned as a fusion partner of the MLL gene in the t(11;19)(q23;p13.1) translocation, which is found in adult myeloid leukemia. MEN belongs to a family of RNA polymerase II elongation factors and dysregulated production of MEN through the MLL promoter could cause malignant transformation of myeloid cells. To pursue the physiological role and determine the requirement of the MEN gene product in mouse development, we generated knockout mice (MEN-/-) by gene targeting in… CONTINUE READING