• Biology, Medicine
  • Published in Journal of immunology 1991

Nonrandom use of J alpha gene segments. Influence of V alpha and J alpha gene location.

@article{Roth1991NonrandomUO,
  title={Nonrandom use of J alpha gene segments. Influence of V alpha and J alpha gene location.},
  author={Matthew E. Roth and Philmore O. Holman and David M. Kranz},
  journal={Journal of immunology},
  year={1991},
  volume={147 3},
  pages={
          1075-81
        }
}
TCR genes (alpha, beta, gamma, and delta) undergo rearrangement during development in the thymus. The repertoire of alpha beta and gamma delta cells is shaped first by genetic processes that control rearrangement and expression and then by intercellular processes that "select" cells expressing only particular receptors. In this report, alpha chain transcripts from different stages of ontogeny were examined to determine the influence of V and J gene location on the thymic repertoire. J alpha… CONTINUE READING

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