Nonrandom packaging of host RNAs in moloney murine leukemia virus.

  title={Nonrandom packaging of host RNAs in moloney murine leukemia virus.},
  author={Adewunmi A Onafuwa-Nuga and Steven R. King and Alice Telesnitsky},
  journal={Journal of virology},
  volume={79 21},
Moloney murine leukemia virus (MLV) particles contain both viral genomic RNA and an assortment of host cell RNAs. Packaging of virus-encoded RNA is selective, with virions virtually devoid of spliced env mRNA and highly enriched for unspliced genome. Except for primer tRNA, it is unclear whether packaged host RNAs are randomly sampled from the cell or specifically encapsidated. To address possible biases in host RNA sampling, the relative abundances of several host RNAs in MLV particles and in… CONTINUE READING


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