Nonrandom Chromosomal Imbalances in Esophageal Squamous Cell Carcinoma Cell Lines: Possible Involvement of the ATF3 and CENPF Genes in the 1q32 Amplicon

@inproceedings{Pimkhaokham2000NonrandomCI,
  title={Nonrandom Chromosomal Imbalances in Esophageal Squamous Cell Carcinoma Cell Lines: Possible Involvement of the ATF3 and CENPF Genes in the 1q32 Amplicon},
  author={Atiphan Pimkhaokham and Yutaka Shimada and Yohji Fukuda and Naoki Kurihara and Issei Imoto and Z Q Yang and Masayuki Imamura and Yusuke Nakamura and Teruo Amagasa and Johji Inazawa},
  booktitle={Japanese journal of cancer research : Gann},
  year={2000}
}
Using comparative genomic hybridization (CGH), we investigated copy number aberrations in 29 esophageal squamous cell carcinoma (ESC) cell lines. All lines displayed numerous chromosome imbalances. The most frequent losses were observed on chromosome 18q (65.5%), Xp (48. 3%), 3p (44.8%), 4q (44.8%), 8p (41.4%), 11q23 - 25 (34.5%) and 4p (27.6%), whereas the most common copy number gains were noted at 8q (86.2%), 3q (82.8%), 5p (69%), 7p (69%), 20q (65.5%), 9q (55.2%), 11q (55.2%), 1q (48.3… CONTINUE READING
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