Nonproteolytic role for the urokinase receptor in cellular migration in vivo.

@article{Waltz2000NonproteolyticRF,
  title={Nonproteolytic role for the urokinase receptor in cellular migration in vivo.},
  author={David Waltz and Rodney M Fujita and Xiaodong Yang and L R Natkin and Shaoqiu Zhuo and Craig J. Gerard and Steven Rosenberg and Harold A Chapman},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={22 3},
  pages={316-22}
}
The urokinase receptor (uPAR) binds and localizes urokinase activity at cellular surfaces, facilitating fibrinolysis and cellular migration at sites of tissue injury. uPAR also participates in cellular signaling and regulates integrin-dependent adhesion and migration in vitro. We now report evidence that uPAR occupancy regulates cellular migration in vivo in the absence of functional urokinase. Recombinant murine KC (1.5 microg), a potent neutrophil chemoattractant, was delivered to the lungs… CONTINUE READING