Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation.

@article{Seligman2005NonproteinTA,
  title={Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation.},
  author={Judith Seligman and Gerald L. Newton and Robert Fahey and Ruth Shalgi and Nechama S. Kosower},
  journal={Journal of andrology},
  year={2005},
  volume={26 5},
  pages={629-37; discussion 638-40}
}
Sperm thiol oxidation during sperm maturation is important for sperm component stabilization, the acquisition of sperm motility, and fertilizing ability. A correct degree of oxidation is required, since spermatozoa are very susceptible to oxidative damage. The pathways involved in physiologic sperm thiol oxidation in the epididymis are not completely understood. The nonprotein thiol glutathione (GSH), in addition to playing a major role as an antioxidant and in eliminating toxic compounds, has… CONTINUE READING
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