Nonpareil: a redundancy-based approach to assess the level of coverage in metagenomic datasets

@article{RodriguezRojas2014NonpareilAR,
  title={Nonpareil: a redundancy-based approach to assess the level of coverage in metagenomic datasets},
  author={Luis Miguel Rodriguez-Rojas and Konstantinos T. Konstantinidis},
  journal={Bioinformatics},
  year={2014},
  volume={30 5},
  pages={629-35}
}
MOTIVATION Determining the fraction of the diversity within a microbial community sampled and the amount of sequencing required to cover the total diversity represent challenging issues for metagenomics studies. Owing to these limitations, central ecological questions with respect to the global distribution of microbes and the functional diversity of their communities cannot be robustly assessed. RESULTS We introduce Nonpareil, a method to estimate and project coverage in metagenomes… CONTINUE READING