Nonparametric overdose control with late-onset toxicity in phase I clinical trials.

@article{Lin2017NonparametricOC,
  title={Nonparametric overdose control with late-onset toxicity in phase I clinical trials.},
  author={Ruitao Lin and Guosheng Yin},
  journal={Biostatistics},
  year={2017},
  volume={18 1},
  pages={180-194}
}
Under the framework of Bayesian model selection, we propose a nonparametric overdose control (NOC) design for dose finding in phase I clinical trials. Each dose assignment is guided via a feasibility bound, which thereby can control the number of patients allocated to excessively toxic dose levels. Several aspects of the NOC design are explored, including the coherence property in dose assignment, calibration of design parameters, and selection of the maximum tolerated dose (MTD). We further… CONTINUE READING