Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast

@article{Lam2015NonparadoxicalES,
  title={Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast},
  author={Isabel Lam and Scott Keeney},
  journal={Science},
  year={2015},
  volume={350},
  pages={932-937}
}
The nonrandom distribution of meiotic recombination shapes heredity and genetic diversification. Theoretically, hotspots—favored sites of recombination initiation—either evolve rapidly toward extinction or are conserved, especially if they are chromosomal features under selective constraint, such as promoters. We tested these theories by comparing genome-wide recombination initiation maps from widely divergent Saccharomyces species. We find that hotspots frequently overlap with promoters in the… CONTINUE READING
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