Nonoxynol-9 enhances rectal infection by herpes simplex virus in mice.

Pretreating the rectum of mice with nonoxynol-9 (N9) or spermicides containing N9 before infecting via the rectal route with herpes simplex virus 2 (HSV-2) increased the likelihood of infection and shortened the time until infection. Microscopic analysis indicated that N9 rapidly caused exfoliation of the rectal epithelium, exposing the underlying… CONTINUE READING