Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

  title={Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.},
  author={Andr{\'e} Delacourte and Nicolas Sergeant and Danie Champain and Annick Wattez and Claude Alain Maurage and Florence Lebert and Florence Pasquier and J. David},
  volume={59 3},
OBJECTIVE To determine the spatiotemporal mapping of tau pathologies and insoluble pools of Abeta in aging and sporadic AD, and their contribution to the physiopathologic, clinical, and neuropathologic features. METHODS The authors studied 130 patients of various ages and different cognitive status, from nondemented controls (n = 60) to patients with severe definite AD (n = 70) who were followed prospectively. Insoluble Abeta 42 and 40 species were fully solubilized and quantified in the main… CONTINUE READING


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