Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code.

Abstract

Insertion of lysine during protein synthesis depends on the enzyme lysyl-tRNA synthetase (LysRS), which exists in two unrelated forms, LysRS1 and LysRS2. LysRS1 has been found in most archaea and some bacteria, and LysRS2 has been found in eukarya, most bacteria, and a few archaea, but the two proteins are almost never found together in a single organism… (More)

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@article{Jester2003NonorthologousRO, title={Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code.}, author={Brian C. Jester and Jeffrey D. Levengood and H. Roy and Michael Ibba and K. Devine}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2003}, volume={100 24}, pages={14351-6} }