Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance.

@article{McGilvray2000NonopsonicMP,
  title={Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance.},
  author={Ian D. McGilvray and Lena Serghides and Andr{\'a}s Kapus and Ori D. Rotstein and Kevin C Kain},
  journal={Blood},
  year={2000},
  volume={96 9},
  pages={3231-40}
}
Plasmodium falciparum is the most lethal form of malaria and is increasing both in incidence and in its resistance to antimalarial agents. An improved understanding of the mechanisms of malarial clearance may facilitate the development of new therapeutic interventions. We postulated that the scavenger receptor CD36, an important factor in cytoadherence of P falciparum-parasitized erythrocytes (PEs), might also play a role in monocyte- and macrophage-mediated malarial clearance. Exposure of… CONTINUE READING

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