Nonoperative Treatment of Rotator Cuff Disease With Platelet-Rich Plasma: A Systematic Review of Randomized Controlled Trials.

@article{Hurley2019NonoperativeTO,
  title={Nonoperative Treatment of Rotator Cuff Disease With Platelet-Rich Plasma: A Systematic Review of Randomized Controlled Trials.},
  author={Eoghan T. Hurley and Charles P. Hannon and Leo Pauzenberger and Daren Lim Fat and Cathal J. Moran and Hannan Mullett},
  journal={Arthroscopy : the journal of arthroscopic \& related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association},
  year={2019},
  volume={35 5},
  pages={
          1584-1591
        }
}
  • E. Hurley, C. P. Hannon, H. Mullett
  • Published 1 May 2019
  • Medicine
  • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Application of Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: A Systematic Review and Meta-analysis
TLDR
It is indicated that arthroscopic rotator cuff repair with PRP significantly reduced the long-term retear rate and shoulder pain and provided improved long- term shoulder function in patients.
Can platelet-rich plasma injections provide better pain relief and functional outcomes in persons with common shoulder diseases: a meta-analysis of randomized controlled trials
TLDR
PRP injections have a greater capacity to improve shoulder-related QoL than other interventions and could provide better pain relief and functional outcomes than other treatments for persons presenting with common shoulder diseases.
Conservative treatment of partial-thickness rotator cuff tears and tendinopathy with platelet-rich plasma: A systematic review and meta-analysis
TLDR
The results suggested platelet-rich plasma had positive effects on pain relief and functional improvement for partial-thickness rotator cuff tears and rotators cuff tendinopathy, although the effects may not last for a long time.
The Effect of Platelet-Rich Plasma Leukocyte Concentration on Arthroscopic Rotator Cuff Repair: A Network Meta-analysis of Randomized Controlled Trials
TLDR
LP-PRP was found to significantly reduce the rate of retear and/or incomplete tendon healing after fixation, even among medium-large tears; it also improved outcomes on the visual analog scale for pain, Constant score, and University of California Los Angeles score.
The effect of physiotherapy in rotator cuff injury patients with platelet-rich plasma: study protocol of a non-randomized controlled trial
TLDR
Whether Platelet-rich plasma (PRP) combined with early physiotherapy has an advantage over PRP alone for rotator cuff injury patients, regarding pain release, function score, tear size, and quality of life improvement is identified.
Platelet Rich Plasma in Patients with Partial Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared to Corticosteroid Injection: A Double-blind Randomized Controlled Trial.
  • Cory Kwong, J. Woodmass, I. Lo
  • Medicine
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2020
Non-operative orthobiologic use for rotator cuff disorders and glenohumeral osteoarthritis: A systematic review.
TLDR
Orthobiologics offer a relatively safe management option with inconclusive evidence for or against its use for rotator cuff pathology, and results were mixed.
Subacromial Platelet Rich Plasma Injections Decrease Pain and Improve Functional Outcomes in Patients with Refractory Rotator Cuff Tendinopathy.
  • L. Rossi, N. Piuzzi, M. Ranalletta
  • Medicine
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2021
Use of Platelet-Rich Plasma for the Improvement of Pain and Function in Rotator Cuff Tears: Letter to the Editor
TLDR
The authors’ belief is that while PRP on its own may not impact functional outcomes, its ability to improve rotator cuff healing then allows for improved functional outcomes.
Editorial Commentary: Platelet-Rich Plasma for Rotator Cuff Repairs: No Evidence for Improved Long-Term Outcomes … Yet!
  • E. Hurley
  • Biology, Medicine
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2022
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References

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Platelet-Rich Plasma Injections in the Treatment of Chronic Rotator Cuff Tendinopathy
TLDR
At 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program.
Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled Trial
TLDR
Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective.
Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial
TLDR
The findings suggest that treatment with platelet-rich plasma injections is safe and useful for rotator cuff disease and lead to a progressive reduction in the pain and disability when compared to dry needling.
Platelet-Rich Plasma Injection With Arthroscopic Acromioplasty for Chronic Rotator Cuff Tendinopathy
TLDR
Arthroscopic acromioplasty significantly improves long-term clinical outcomes up to 2 years and significantly alters the tissue characteristics in tendons after surgery with reduced cellularity and vascularity and increased levels of apoptosis.
Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears
TLDR
PRP injections showed earlier better results as compared to corticosteroid injections, although statistically significant better results after 6 months could not be found, therefore, subacromial RPP injection could be considered as a good alternative to cortiosteroid injection, especially in patients with a contraindication to cortICosteroid administration.
Platelet-rich plasma in tendon models: a systematic review of basic science literature.
Platelet-Rich Plasma Treatment With Physical Therapy in Chronic Partial Supraspinatus Tears
TLDR
When compared with PT, PRP seemed to be a well-tolerated application which showed promising results in patients with chronic partial supraspinatus tears.
Arthroscopic surgery compared with supervised exercises in patients with rotator cuff disease (stage II impingement syndrome)
TLDR
Surgery or a supervised exercise regimen significantly, and equally, improved rotator cuff disease compared with placebo in both groups given the active treatments.
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