Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men.

@article{Stephens2001NonnoradrenergicMO,
  title={Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men.},
  author={Dan P Stephens and Ken Aoki and Wojciech A Kosiba and John M. Johnson},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 4},
  pages={H1496-504}
}
We tested for a nonnoradrenergic mechanism of reflex cutaneous vasoconstriction with whole body progressive cooling in seven men. Forearm sites (<1 cm(2)) were pretreated with: 1) yohimbine (Yoh; 5 mM id) to antagonize alpha-adrenergic receptors, 2) Yoh plus propranolol (5 mM Yoh-1 mM PR id) to block alpha- and beta-adrenergic receptors, 3) iontophoretic application of bretylium tosylate (BT) to block all sympathetic vasoconstrictor nerve effects, or 4) intradermal saline. Skin blood flow was… CONTINUE READING

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Cutaneous vascular responses to local cooling: roles of pre- and post-synaptic sympathetic blockade (Abstract)

  • JM Johnson, N Charkoudian, J Johnson, L LaGrange, WA. Kosiba
  • FASEB J 12:
  • 1997
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