Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

@article{Thompson2008NonnightmareDA,
  title={Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.},
  author={Charles L. Thompson and Fletcher B. Taylor and Miles E. McFall and Robert F. Barnes and Murray A. Raskind},
  journal={Journal of traumatic stress},
  year={2008},
  volume={21 4},
  pages={417-20}
}
Twenty-two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma-related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha-1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma-related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain… CONTINUE READING

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