Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

  title={Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.},
  author={Charles L. Thompson and Fletcher B. Taylor and Miles E. McFall and Robert F. Barnes and Murray A. Raskind},
  journal={Journal of traumatic stress},
  volume={21 4},
Twenty-two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma-related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha-1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma-related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain… CONTINUE READING


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Prazosin effects on objective sleepmeasures and clinical symptoms in civilian trauma PTSD : A placebo - controlled study

  • F. B. Taylor, P. Martin, C. Thompson, J. Williams, T. A. Mellman, C. Gross
  • Biological Psychiatry
  • 2008
3 Excerpts

Disordered sleep in posttraumatic stress disorder : Clinical presentation , research , findings , and implications for treatment

  • A. Golbin, H. Kravitz, L. G. Keith
  • Sleep psychiatry
  • 2004

Heart rate variability during sleep and the early development of posttraumatic stress disorder

  • D. B. Menkes, J. M. Baraban, G. K. Aghajanian
  • Biological Psychiatry
  • 2004

Noctur - nal / daytime urine noradrenergic measures and sleep in combat - related PTSD

  • T. A. Mellman, B. R. Knorr, W. R. Pigeon, J. C. Leiter, M. Akay
  • Biological Psychiatry
  • 1995

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