Nonneural beta‐adrenergic vasodilating mechanism in temperature biofeedback.

  title={Nonneural beta‐adrenergic vasodilating mechanism in temperature biofeedback.},
  author={Robert R. Freedman and S. C. Sabharwal and Peter Ianni and N Desai and Paul Wenig and Maureen D. Mayes},
  journal={Psychosomatic Medicine},
&NA; Although finger temperature feedback has been used to produce digital vasodilation in normal persons and those with Raynaud's disease, the mechanism and site of this effect have not been studied. In the present investigation, feedback‐induced vasodilation was attenuated by brachial artery infusions of propranolol in infused, but not contralateral, hands and was not affected by digital nerve blockade. Quantitative measurements of finger blood flow demonstrated that this vasodilation… Expand
Physiological mechanism of digital vasoconstriction training
Temperature feedback vasoconstriction training is mediated through an efferent, sympathetic nervous pathway, in contrast to temperature feedback vasodilation training, which is mediatedthrough a nonneural, beta-adrenergic mechanism. Expand
Quantitative measurements of finger blood flow during behavioral treatments for Raynaud's disease.
Temperature feedback subjects showed significant elevations in finger blood flow, finger temperature, and skin conductance level, whereas those who received autogenic training did not, which are consistent with previous studies suggesting the involvement of an active vasodilating mechanism in temperature feedback. Expand
Physiological mechanisms of temperature biofeedback
Research on the physiological mechanisms of finger temperature biofeedback with normal subjects and Raynaud's disease patients is reviewed, and feedback-induced vasodilation is shown to be mediated through a non-neural, β-adrenergic mechanism rather than through reductions in sympathetic nervous system activation. Expand
Plasma catecholamines during behavioral treatments for Raynaud's disease.
Findings do not support the role of decreased sympathetic activation in behavioral treatments for Raynaud's disease and no significant effects for norepinephrine and epinephrine for either group. Expand
Physiological Mechanisms Biofeedback I
Research on the physiological mechanisms of finger temperature biofeedback with normal subjects and Raynaud's disease patients is reviewed. Studies conducted in the author's laboratory have shownExpand
Adrenergic receptors in the forehead microcirculation
It is indicated that α-adrenoceptors in the forehead microcirculation normally mediate a vasoconstrictor response to iontophoretically-applied noradrenaline and, in addition, β-adRenoceptor appear to mediated a minor vasodilator component of response. Expand
Plasma catecholamine levels during temperature biofeedback training in normal subjects
Data do not support the hypothesis that feedback-induced vasodilation is accompanied by decreased sympathetic activation in normal populations, when only temperature biofeedback is employed. Expand
Temperature biofeedback for Raynaud's syndrome.
Recent work on the treatment of idiopathic Raynaud's disease with biofeedback and the mechanisms of this treatment would be relevant and demonstrated that elevations in finger temperature were accompanied by increased finger temperature. Expand
Training to vasodilate in a cooling environment: A valid treatment for Raynaud's phenomenon?
The results in 14 patients with primary and secondary Raynaud's phenomenon indicated that patients learned to voluntarily increase digital skin temperatures in a “cooling” environment during documented vasoconstriction, and there was a 31% decrease in the occurrence of vasospastic attacks following such learning. Expand
Long-term effectiveness of behavioral treatments for Raynaud's disease
Temperature biofeedback reduces reported symptom frequency and enables patients to voluntarily increase finger temperature and capillary blood flow for 1 year after treatment, and relaxation-based procedures produce smaller symptom reductions at one-year follow-up with no retention of physiological effects. Expand


Beta-adrenergic vasodilator mechanism in the finger.
It is concluded that there is a beta-adrenergic vasodilator mechanism in human digital arteriovenous shunts that may be humorally activated, but which has no apparent functional role in modulating sympathetic vasoconstriction. Expand
Total and capillary fingertip blood flow in Raynaud's phenomenon.
Patients with Raynaud's phenomenon have a smaller finger nutritional flow than normal subjects, and this flow decreases during reflex sympathetic nerve stimulation by body cooling, while during oral reserpine treatment, 11 patients showed a significantly larger capillary flow. Expand
Self-control of digital temperature: physiological factors and transfer effects.
It is concluded that consistent finger temperature elevations during training are necessary for generalization of this response outside the laboratory and relaxation was not necessary for temperature elevation in the laboratory, it might have enhanced this effect outside the Laboratory setting. Expand
Behavioral treatment of Raynaud's disease
All trained subjects demonstrated a significant ability to maintain digital skin temperature in the presence of a cold stress challenge and reported significant reductions in both frequency and intensity of vasospastic attacks. Expand
Standstill of nailfold capillary blood flow during cooling in scleroderma and Raynaud's syndrome.
It is concluded that capillary microscopy can separate SD and RS patients from control subjects during cold exposure and may be useful in early diagnosis and prognosis of rheumatic syndromes and in the evaluation of therapy designed to improve the nutritional capillary blood flow of the skin. Expand
Conditioning Changes in Differential Skin Temperature
  • F. Keefe
  • Materials Science, Medicine
  • Perceptual and motor skills
  • 1975
Differential changes in skin temperature correlated highly with changes in absolute finger temperature, and these results are discussed as relevant to the clinical application of skin temperature control. Expand
Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders.
The prevalence of scleroderma-type capillary abnormalities, as observed by in vivo microscopy, was determined in 173 patients from three rheumatic disease centers, finding enlarged and deformed capillary loops surrounded by relatively avascular areas, most prominently in the nail-folds were found in 82% of patients with sclerodma and in 54% with mixed connective tissue disease. Expand
Behavioral treatment of Raynaud's disease: long-term follow-up.
Learned control of skin temperature
  • Behav Ther 10:202-10,
  • 1979