Nonnative intermediate state of acid-stable beta-sheet protein.

  title={Nonnative intermediate state of acid-stable beta-sheet protein.},
  author={Jenny J. Yang and Amy R. Carroll and Weixing Yang and Yiming Ye and Christina N. Nguyen},
  journal={Cell biochemistry and biophysics},
  volume={33 3},
Cell adhesion molecule, CD2, from the immunoglobulin superfamily, is comprised of antibodies and Ig-like domains and plays a fundamental role, not only in the immune system, but also in the interactions between cells, specifically in cell-cell adhesion. This study examines the N-terminal domain 1 of CD2 (CD2-1) at different pHs, and in 2,2,2-trifluoroethanol (TFE), using nears- and far-UV circular dichroism (CD), fluorescence, and 1H nuclear magnetic resonance to elucidate factors contributing… CONTINUE READING

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