Nonmuscle myosin II is required for internalization of the epidermal growth factor receptor and modulation of downstream signaling.

@article{Kim2012NonmuscleMI,
  title={Nonmuscle myosin II is required for internalization of the epidermal growth factor receptor and modulation of downstream signaling.},
  author={Jong Hyun Kim and Aibing Wang and Mary Anne Conti and Robert S Adelstein},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 33},
  pages={27345-58}
}
Ligand-induced internalization of the epidermal growth factor receptor (EGFR) is an important process for regulating signal transduction, cellular dynamics, and cell-cell communication. Here, we demonstrate that nonmuscle myosin II (NM II) is required for the internalization of the EGFR and to trigger the EGFR-dependent activation of ERK and AKT. The EGFR was identified as a protein that interacts with NM II by co-immunoprecipitation and mass spectrometry analysis. This interaction requires… CONTINUE READING
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