Nonmicrocephalic Infants with Congenital Zika Syndrome Suspected Only after Neuroimaging Evaluation Compared with Those with Microcephaly at Birth and Postnatally: How Large Is the Zika Virus "Iceberg"?

@article{Aragao2017NonmicrocephalicIW,
  title={Nonmicrocephalic Infants with Congenital Zika Syndrome Suspected Only after Neuroimaging Evaluation Compared with Those with Microcephaly at Birth and Postnatally: How Large Is the Zika Virus "Iceberg"?},
  author={M F V V Aragao and A C Holanda and A M Brainer-Lima and N C L Petribu and M Castillo and V van der Linden and S C Serpa and A G Ten{\'o}rio and P T C Travassos and Marli Cordeiro and C Sarteschi and M M Valença and Anthony Costello},
  journal={AJNR. American journal of neuroradiology},
  year={2017},
  volume={38 7},
  pages={1427-1434}
}
BACKGROUND AND PURPOSE Although microcephaly is the most prominent feature of congenital Zika syndrome, a spectrum with less severe cases is starting to be recognized. Our aim was to review neuroimaging of infants to detect cases without microcephaly and compare them with those with microcephaly. MATERIALS AND METHODS We retrospectively evaluated all neuroimaging (MR imaging/CT) of infants 1 year of age or younger. Patients with congenital Zika syndrome were divided into those with… CONTINUE READING
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