Nonmammalian nuclear receptors : Evolution and endocrine disruption *

  title={Nonmammalian nuclear receptors : Evolution and endocrine disruption *},
  author={Joseph W. Thornton},
Most research to identify endocrine-disrupting chemicals and their impacts has relied on mammalian models or in vitro systems derived from them. But nuclear receptors (NRs), the proteins that transduce hydrophobic hormonal signals and are major mediators of endocrine disruption, emerged early in animal evolution and now play biologically essential roles throughout the Metazoa. Nonmammalian vertebrates and invertebrates, many of which are of considerable ecological, economic, and cultural… CONTINUE READING


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