Nonlinearity of Mechanochemical Motions in Motor Proteins

@article{Togashi2010NonlinearityOM,
  title={Nonlinearity of Mechanochemical Motions in Motor Proteins},
  author={Y. Togashi and T. Yanagida and A. Mikhailov},
  journal={PLoS Computational Biology},
  year={2010},
  volume={6}
}
The assumption of linear response of protein molecules to thermal noise or structural perturbations, such as ligand binding or detachment, is broadly used in the studies of protein dynamics. Conformational motions in proteins are traditionally analyzed in terms of normal modes and experimental data on thermal fluctuations in such macromolecules is also usually interpreted in terms of the excitation of normal modes. We have chosen two important protein motors — myosin V and kinesin KIF1A — and… Expand
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  • 17
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References

SHOWING 1-10 OF 47 REFERENCES
Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
  • 439
  • PDF
Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.
  • Tirion
  • Physics, Medicine
  • Physical review letters
  • 1996
  • 1,410
  • PDF
A comparative study of motor-protein motions by using a simple elastic-network model
  • Wenjun Zheng, S. Doniach
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
  • 199
  • PDF
Analysis of domain motions by approximate normal mode calculations
  • 678
  • PDF
Protein normal-mode dynamics: trypsin inhibitor, crambin, ribonuclease and lysozyme.
  • 636
  • PDF
Mesoscale modeling of molecular machines: cyclic dynamics and hydrodynamical fluctuations.
  • 45
  • PDF
Elastic network models for understanding biomolecular machinery: from enzymes to supramolecular assemblies.
  • 139
  • PDF
Violation of the fluctuation-dissipation theorem in a protein system.
  • 18
  • PDF
...
1
2
3
4
5
...