Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution.

@article{Gustafsson2005NonlinearSM,
  title={Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution.},
  author={Mats G. Gustafsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 37},
  pages={13081-6}
}
Contrary to the well known diffraction limit, the fluorescence microscope is in principle capable of unlimited resolution. The necessary elements are spatially structured illumination light and a nonlinear dependence of the fluorescence emission rate on the illumination intensity. As an example of this concept, this article experimentally demonstrates saturated structured-illumination microscopy, a recently proposed method in which the nonlinearity arises from saturation of the excited state… CONTINUE READING
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