Nonlinear rheology of cellular networks.

  title={Nonlinear rheology of cellular networks.},
  author={Charlie Duclut and Joris Paijmans and Mandar M. Inamdar and Carl D. Modes and Frank J{\"u}licher},
  journal={Cells \& development},

Effect of cellular rearrangement time delays on the rheology of vertex models for confluent tissues

This work suggests that molecular mechanisms that act as a brake on T1 transitions could stiffen global tissue mechanics and enhance rosette formation during morphogenesis.

Shear-driven solidification and nonlinear elasticity in epithelial tissues

This work uses a minimal cell-based computational model to investigate the constitutive relation of confluent tissues under simple shear deformation and shows that an initially undeformed fluidlike tissue acquires finite rigidity above a critical applied strain.

Active T1 transitions in cellular networks

Abstract In amorphous solids as in tissues, neighbor exchanges can relax local stresses and allow the material to flow. In this paper, we use an anisotropic vertex model to study T1 rearrangements in

Boundary-bulk patterning in three-dimensional confluent cellular collectives

The use of a cellular-based approach to designing organoids with new types of morphologies to study the intricate relationship between structure and function at the multi-cellular scale is discussed.

3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo

A fully 3D vertex-like (Voronoi) model for the tissue architecture is developed, and it is demonstrated that the tissue can generate drag forces and drive cell shape changes, suggesting that 3D viscoelastic drag forces could be a generic mechanism for cell shape change in other biological processes.

Symmetry, Thermodynamics, and Topology in Active Matter

Mark J. Bowick, Nikta Fakhri, M. Cristina Marchetti, and Sriram Ramaswamy Kavli Institute for Theoretical Physics, University of California Santa Barbara, Santa Barbara, CA 93106, USA Department of

Optogenetic dissection of actomyosin-dependent mechanics underlying tissue fluidity

This work uses two optogenetic tools, optoGEF and optoGAP, to manipulate Rho/Rho-kinase signaling and actomyosin contractility in the germband epithelium, which flows via convergent extension movements during Drosophila body axis elongation to dissect the roles of actomyOSin in the mechanics of epithelial tissue flows.



The role of fluctuations and stress on the effective viscosity of cell aggregates

This work develops a mechanical model of aggregates based on their cellular structure and discusses the deviations from liquid behavior, the possible overestimation of surface tension in parallel-plate compression measurements, and the role of measurement duration.

Nonlinear Rheology in a Model Biological Tissue.

A particle-based model featuring random apoptosis and environment-dependent division rates is used to evidence a crossover from linear flow to a shear-thinning regime with an increasing shear rate, and a theoretical mean-field scenario is derived that accounts for the interplay of mechanical and active noise in local stresses.

Fluidization of epithelial sheets by active cell rearrangements.

A coarse-grained theory is developed, where the tissue is treated as an active fluid and the impact of cell rearrangements on tissue shape is illustrated by studying axial compression of an epithelial tube.

The plastic cell: mechanical deformation of cells and tissues

New and exciting findings dissecting some of the physical principles and molecular mechanisms accounting for irreversible cell shape changes are reviewed, including concepts of mechanical ratchets and tension thresholds required to induce permanent cell deformations akin to mechanical plasticity.

Fluidization of tissues by cell division and apoptosis

A continuum description of tissue dynamics is developed, which describes the stress distribution and the cell flow field on large scales and shows that the tissue effectively behaves as a viscoelastic fluid with a relaxation time set by the rates of division and apoptosis.

Migrating Epithelial Monolayer Flows Like a Maxwell Viscoelastic Liquid.

In this experiment, the monolayer behaves as a flowing material with a Weissenberg number close to one which shows that both elastic and viscous effects can have comparable contributions in the process of collective cell migration.

Hydrodynamic theory of tissue shear flow

It is shown that anisotropic deformation of tissue and cells can arise from two distinct active cellular processes: generation of active stress in the tissue and actively driven cellular rearrangements, depending on boundary conditions applied on the tissue.

Triangles bridge the scales: how cellular processes cause tissue deformation

This article proposes a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues and discusses tissue remodeling in the developing pupal wing of the fly Drosophila melanogaster.