Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brainin vivo

  title={Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brainin vivo
  author={Karima Chergui and Marie-Françoise Suaud-Chagny and François G. Gonon},

Inhibition of Dopamine Release Via Presynaptic D2 Receptors: Time Course and Functional Characteristics In Vivo

Dopamine release was evoked in the striatum of anesthetized mice by electrical stimulation of the medial forebrain bundle and was continuously monitored by amperometry using carbon fiber electrodes and autoinhibition eliciting by one burst transiently attenuates further dopamine release elicited by tonic activity.

Presynaptic regulation of dendrodendritic dopamine transmission

Dendritic dopamine release was examined in the substantia nigra and ventral tegmental area in mouse brain slices using whole‐cell recording of a dopamine‐mediated inhibitory postsynaptic current (IPSC) and it was demonstrated that presynaptic D2‐autoreceptors did not contribute to the depression.

Paradoxical modulation of short‐term facilitation of dopamine release by dopamine autoreceptors

The data demonstrate that the commanding control exerted by dopamine autoreceptors over short‐term neuroadaptation of dopamine release involves both inhibitory and paradoxically, facilitatory components.

Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat Striatum In Vivo

  • F. Gonon
  • Biology
    The Journal of Neuroscience
  • 1997
The spatiotemporal characteristics of the dopaminergic transmission mediated by D1 receptors were investigated in vivo. For this purpose dopamine (DA) release was evoked in the striatum of

Time window of autoreceptor‐mediated inhibition of limbic and striatal dopamine release

Autoreceptor‐mediated modulation of forebrain dopamine release was investigated using amperometry in brain slices following local electrical stimulation and the onset time is due both to diffusion of dopamine from the release sites to the autoreceptors and receptor‐effector mechanisms.

Theory for the impact of basal turnover on dopamine clearance kinetics in the rat striatum after medial forebrain bundle stimulation and pressure ejection

A new kinetic analysis of dopamine uptake is introduced that sheds light on the possible source of the different clearance rates observed following evoked dopamine release and dopamine pressure ejection and rationalizes the rapid dopamine clearance after evoked release with the possibility that basal extracellular dopamine levels are above the KM of the transporter.

Two different Ca2+‐dependent inhibitory mechanisms of spontaneous firing by glutamate in dopamine neurons

It is shown that the bursts in spontaneously firing dopamine neurons can be generated by the combinative actions of the brief stimulatory and the subsequent Ca2+‐dependent inhibitory signals in response to glutamate stimulation.



Effects of Frequency and Pattern of Medial Forebrain Bundle Stimulation on Caudate Dialysate Dopamine and Serotonin

In vivo microdialysis was employed to detect changes in extracellular dopamine and serotonin in the rat caudate in response to electrical stimulation of the medial forebrain bundle, and results suggest that micro dialysis can be used to detect physiological changes in synaptic transmitter concentrations.

The control of firing pattern in nigral dopamine neurons: single spike firing

  • A. GraceB. Bunney
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1984
In vivo intracellular injection of the calcium chelator EGTA will cause DA cells to fire in a regular, pacemaker pattern, with the amplitude of the afterhyperpolarization being proportional to the number of spikes in a train.

Firing patterns of midbrain dopamine neurons: differences between A9 and A10 cells.

The results show that although A9 and A10 do not differ in firing rates, A10 neuronal activity is markedly less regular and shows a higher degree of burst firing, as judged from analysis of inter-spike time interval histograms.

Differentiation of Dopamine Overflow and Uptake Processes in the Extracellular Fluid of the Rat Caudate Nucleus with Fast‐Scan In Vivo Voltammetry

Stimulated overflow of dopamine into the extracellular fluid of the rat caudate nucleus was measured with fast‐scan cyclic voltammetry and the effects of GBR 12909 best correlated with an increase in the DA available for overflow.

Differences in evoked dopamine efflux in rat caudate putamen, nucleus accumbens and tuberculum olfactorium in the absence of uptake inhibition: influence of autoreceptors

Experiments with sulpiride or metoclopramide (dopamine D2 receptor antagonists) indicate that dopamine release in the caudate putamen is not regulated by dopamine autoreceptor activation by endogenous dopamine under the authors' experimental conditions (in the absence of reuptake inhibtion).