Nonlinear pharmacokinetics of tissue-type plasminogen activator in three animal species: a comparison of mathematical models.

Abstract

A recent study presented plasma concentrations of tissue-type plasminogen activator in three different animal species and at several different dose levels. A three-compartment mammillary model with capacity-limited elimination (of Michaelis-Menten form) was postulated to describe the data. In the present study, several alternative model structures are… (More)

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@article{Godfrey1998NonlinearPO, title={Nonlinear pharmacokinetics of tissue-type plasminogen activator in three animal species: a comparison of mathematical models.}, author={K. R. Godfrey and Paul Tanswell and Ruthann Bates and M Jahi Chappell and Francis N. Madden}, journal={Biopharmaceutics & drug disposition}, year={1998}, volume={19 2}, pages={131-40} }