Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys.

@article{Balani1999NonlinearPO,
  title={Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys.},
  author={Suresh K. Balani and Lindy Kauffman and F A Deluna and Jiunn Huei Lin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 1},
  pages={41-5}
}
Efavirenz (EFV, Sustiva, Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Pharmacokinetics of EFV was studied in rats and monkeys, the safety assessment species. In rats, after 2 and 5 mg/kg i.v. administrations, the mean CLp, Vdss, and T1/2 were 67 ml/min/kg, 5.0 liters/kg, and 1 h, respectively. EFV was metabolized completely, and the products were excreted almost exclusively via bile. At the higher dose of 15 mg/kg, the CLp was… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

A double-blind pilot study to evaluate the antiretroviral activity, tolerability of DMP 266 alone and in combination with indinavir

N Ruiz, S Riddler, +6 authors D Labriola
Presented at “Retroviruses, 4th Annual Conference,” • 1997
View 1 Excerpt

Long - term anti - HIV activity and tolerability of DMP 266 in combination with indinavir ( IDV )

J Kahn, D Mayers, +4 authors N Ruiz
1997
View 1 Excerpt

Oral bioavailability and first-pass effects.

Drug metabolism and disposition: the biological fate of chemicals • 1997
View 1 Excerpt

Pharmacokinetics of DMP 266 and indinavir multiple oral doses in HIV-1 infected individuals. Presented at Retroviruses

WD Fiske, D Mayers, +6 authors J Kahn
4th Annual Conference, • 1997
View 2 Excerpts

Pharmacokinetics, safety and tolerability of single escalating doses of efavirenz (DMP 266), an HIV-1 non-nucleoside reverse transcriptase inhibitor, in healthy volunteers

WD Fiske, WL Finan, CA Robinson, JM Connell, DM Kornhauser
Presented at the AAPS Meeting, • 1997
View 2 Excerpts

Structural mechanisms of HIV drug resistance.

Annual review of pharmacology and toxicology • 1996
View 3 Excerpts

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