Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.

@article{Concheiro2014NonlinearPO,
  title={Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.},
  author={Marta Concheiro and Michael Heinrich Baumann and Karl B. Scheidweiler and Richard B. Rothman and Gina F Marrone and Marilyn A Huestis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2014},
  volume={42 1},
  pages={119-25}
}
3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Preclinical studies to determine MDMA's safety are needed. We evaluated MDMA's pharmacokinetics and metabolism in male rats receiving 2.5, 5, and 10 mg/kg s.c. MDMA, and the associated pharmacodynamic consequences. Blood was collected via jugular… CONTINUE READING
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