Nonlinear blending: a useful general concept for the assessment of combination drug synergy.

@article{Peterson2007NonlinearBA,
  title={Nonlinear blending: a useful general concept for the assessment of combination drug synergy.},
  author={John J. Peterson and Steven J Novick},
  journal={Journal of receptor and signal transduction research},
  year={2007},
  volume={27 2-3},
  pages={125-46}
}
Human diseases may involve cellular signaling networks that contain redundant pathways, so that blocking a single pathway in the system cannot achieve the desired effect. As such, the use of drugs in combination are particularly effective interventions in networked systems. However, common synergy measures are often inadequate to quantify the effect of two different drugs in complex cellular systems. This article proposes a general approach to quantifying the synergy of two drugs in combination… CONTINUE READING

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