Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells

@article{Lowe1993NonlinearAB,
  title={Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells},
  author={Graeme Lowe and Geoffrey H. Gold},
  journal={Nature},
  year={1993},
  volume={366},
  pages={283-286}
}
THE sense of smell is highly evolved in mammals, allowing discrimination between a vast number of odorants, with detection thresholds as low as 10−17M (ref. 1). Although several features of mammalian olfactory transduction have been revealed by biochemical and molecular biological studies2–11, the odorant-induced membrane current has remained elusive. In amphibians this current is mediated by cyclic-nucleotide-gated channels12–15, which depolarize the cell by Na+ and Ca+influx16,17 and… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 159 extracted citations

Cyclic-nucleotide-gated cation current and Ca2+-activated Cl current elicited by odorant in vertebrate olfactory receptor neurons.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 5 Excerpts
Highly Influenced

Peripheral adaptation codes for high odor concentration in glomeruli.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 6 Excerpts
Highly Influenced

Unitary response of mouse olfactory receptor neurons.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 3 Excerpts
Highly Influenced

Mechanisms of chloride uptake in frog olfactory receptor neurons

Journal of Comparative Physiology A • 2010
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…